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In this week's issue of Science Signaling:
Research Articles
- Cell Death
Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1–Dependent Cell Death (Parthanatos) - Yingfei Wang, No Soo Kim, Jean-Francois Haince, Ho Chul Kang, Karen K. David, Shaida A. Andrabi, Guy G. Poirier, Valina L. Dawson, and Ted M. Dawson
- Sci. Signal. 4 (167), ra20. [DOI: 10.1126/scisignal.2000902]
Poly(ADP-ribose) binds to apoptosis-inducing factor to trigger its release from mitochondria and induce cell death.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/ra20?etoc - Immunology
Confinement of Activating Receptors at the Plasma Membrane Controls Natural Killer Cell Tolerance - Sophie Guia, Baptiste N. Jaeger, Stefan Piatek, Sébastien Mailfert, Tomasz Trombik, Aurore Fenis, Nicolas Chevrier, Thierry Walzer, Yann M. Kerdiles, Didier Marguet, Eric Vivier, and Sophie Ugolini
- Sci. Signal. 4 (167), ra21. [DOI: 10.1126/scisignal.2001608]
Signaling through inhibitory NK cell receptors determines the distribution, and hence responsiveness, of activating receptors.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/ra21?etoc
Perspectives
- Metabolism
ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism - Antje Krüger and Markus Ralser
- Sci. Signal. 4 (167), pe17. [DOI: 10.1126/scisignal.2001959]
By linking genome stability, the cell cycle, and carbon catabolism, ATM emerges as a central regulator of cancer cell metabolism.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/pe17?etoc - Redox Signaling
All Stressed Out Without ATM Kinase - J. Jefferson P. Perry and John A. Tainer
- Sci. Signal. 4 (167), pe18. [DOI: 10.1126/scisignal.2001961]
Oxidation activates ATM, allowing this kinase to mediate antioxidant responses.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/pe18?etoc
Editors' Choice
- Host-Microbe Interactions
Why Not Take Antibiotics for the Flu? - Elizabeth M. Adler
- Sci. Signal. 4 (167), ec94. [DOI: 10.1126/scisignal.4167ec94]
Some antibiotics dampen the immune response to respiratory infection with influenza virus.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/ec94?etoc - Cell Biology
Pseudoproteases as Inhibitors - Wei Wong
- Sci. Signal. 4 (167), ec95. [DOI: 10.1126/scisignal.4167ec95]
A group of rhomboid-like proteins lacking catalytic activity inhibit EGFR signaling by promoting degradation of EGF family ligands.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/ec95?etoc - Immunology
Genetics of Candidiasis - Kristen L. Mueller
- Sci. Signal. 4 (167), ec96. [DOI: 10.1126/scisignal.4167ec96]
Chronic yeast infections in the absence of other infections result from genetic deficiencies in proinflammatory host responses.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/ec96?etoc - Plant Biology
Plant Ultraviolet Perception - Pamela J. Hines
- Sci. Signal. 4 (167), ec97. [DOI: 10.1126/scisignal.4167ec97]
A plant ultraviolet-B photoreceptor uses a tryptophan-based chromophore.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/ec97?etoc - Cell Biology
Stress Relief - Stella M. Hurtley
- Sci. Signal. 4 (167), ec98. [DOI: 10.1126/scisignal.4167ec98]
Guanabenz, a small-molecule inhibitor, protects cells from lethal accrual of misfolded proteins in the endoplasmic reticulum.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/ec98?etoc
Podcasts
- Immunology
Science Signaling Podcast: 5 April 2011 - Sophie Ugolini, Eric Vivier, and Annalisa M. VanHook
- Sci. Signal. 4 (167), pc7. [DOI: 10.1126/scisignal.2002027]
The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/pc7?etoc
Presentations
- Cell Biology
Proteomic Analysis of Integrin Adhesion Complexes - Adam Byron, Jonathan D. Humphries, Mark D. Bass, David Knight, and Martin J. Humphries
- Sci. Signal. 4 (167), pt2. [DOI: 10.1126/scisignal.2001827]
A workflow for the proteomic analysis of integrin-associated complexes reveals ligand-specific adhesion networks.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/pt2?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to:
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