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 Science Signaling: Print Edition
Weekly online and monthly in print
Learn more
In this week's issue of Science Signaling:
ST NetWatch
- Protein Databases
PTMScout - Description
- Modeling Tools
The Virtual Cell - Description
Research Articles
- Immunology
Inhibitory ITAM Signaling Traps Activating Receptors with the Phosphatase SHP-1 to Form Polarized "Inhibisome" Clusters - Séverine Pfirsch-Maisonnas, Meryem Aloulou, Ting Xu, Julien Claver, Yutaka Kanamaru, Meetu Tiwari, Pierre Launay, Renato C. Monteiro, and Ulrich Blank
- Sci. Signal. 4 (169), ra24. [DOI: 10.1126/scisignal.2001309]
Receptors with activating motifs are captured in inhibitory intracellular compartments and thereby prevented from signaling.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ra24?etoc - Immunology
ERKs Induce Expression of the Transcriptional Repressor Blimp-1 and Subsequent Plasma Cell Differentiation - Tomoharu Yasuda, Kohei Kometani, Noriko Takahashi, Yuuki Imai, Yuichi Aiba, and Tomohiro Kurosaki
- Sci. Signal. 4 (169), ra25. [DOI: 10.1126/scisignal.2001592]
The differentiation of B cells into antibody-producing plasma cells requires extracellular signal–regulated kinases.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ra25?etoc
Perspectives
- Immunology
How ITAMs Inhibit Signaling - Lionel B. Ivashkiv
- Sci. Signal. 4 (169), pe20. [DOI: 10.1126/scisignal.2001917]
ITAM-mediated inhibition recruits SHP-1 to membrane lipid rafts and diverts activated receptors to an inhibitory intracellular compartment.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/pe20?etoc - Immunology
pERKing Up the BLIMP in Plasma Cell Differentiation - David M. Allman and Michael P. Cancro
- Sci. Signal. 4 (169), pe21. [DOI: 10.1126/scisignal.2001987]
Extracellular signal–regulated kinase is critical for the generation of plasma cells.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/pe21?etoc
Editors' Choice
- Sensory Perception
One Channel for Pain and Smell - Nancy R. Gough
- Sci. Signal. 4 (169), ec106. [DOI: 10.1126/scisignal.4169ec106]
Without a functional Nav1.7 sodium channel, not only is the sense of pain lost, but so is the sense of smell.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ec106?etoc - Cell Biology
Assessing Filopodia Form and Function - L. Bryan Ray
- Sci. Signal. 4 (169), ec107. [DOI: 10.1126/scisignal.4169ec107]
Signaling protein receptors are segregated into different cell protrusions in Drosophila cells.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ec107?etoc - Structural Biology
Just the Right Amount (of Activation) - Nancy R. Gough
- Sci. Signal. 4 (169), ec108. [DOI: 10.1126/scisignal.4169ec108]
New structures for the energy-sensing kinase AMPK suggest a potential mechanism for adjusting the amount of activation to suit the cell’s energy status.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ec108?etoc - Immunology
No Receptor Necessary - Elizabeth M. Adler
- Sci. Signal. 4 (169), ec109. [DOI: 10.1126/scisignal.4169ec109]
Alum’s adjuvant action depends on signaling pathways initiated by its binding to dendritic cell membrane lipids.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ec109?etoc - Developmental Biology
Lipids Influence Hippo Signaling - Annalisa M. VanHook
- Sci. Signal. 4 (169), ec110. [DOI: 10.1126/scisignal.4169ec110]
A phosphatidylinositol 4-kinase is required for proper Merlin localization and Hippo signaling during fly oocyte polarization.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ec110?etoc - Cell Biology
Sustained by Degradation - Wei Wong
- Sci. Signal. 4 (169), ec111. [DOI: 10.1126/scisignal.4169ec111]
A ubiquitin E3 ligase promotes degradation of the regulatory subunit of PKA and thus enhances PKA signaling.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ec111?etoc - Physiology
Seeking the Right Pathway - Paula A. Kiberstis
- Sci. Signal. 4 (169), ec112. [DOI: 10.1126/scisignal.4169ec112]
Transforming growth factor–β promotes aortic aneurysm formation through activation of its "noncanonical" signaling pathway.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ec112?etoc - Structural Biology
Adenosine Receptor Activation - Valda Vinson
- Sci. Signal. 4 (169), ec113. [DOI: 10.1126/scisignal.4169ec113]
Changes associated with conformationally selective agonist binding shed light on G protein–coupled receptor activation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/169/ec113?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to:
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