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Explore the personalization options at My Science Signaling.
In this week's issue of Science Signaling:
Glossary
- Find out what c-Yes, Lyn, and R-Smad mean in the world of cell signaling.
- New Terms | Search and Browse the Glossary
Research Articles
- Cancer
Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transcription Factors ERβ and KLF5 - Yuka Nakajima, Kensuke Akaogi, Takashi Suzuki, Asami Osakabe, Chie Yamaguchi, Nanae Sunahara, Junji Ishida, Koichiro Kako, Sonoko Ogawa, Tetsuya Fujimura, Yukio Homma, Akiyoshi Fukamizu, Akiko Murayama, Keiji Kimura, Satoshi Inoue, and Junn Yanagisawa
- Sci. Signal. 4 (168), ra22. [DOI: 10.1126/scisignal.2001551]
Estrogens and antiestrogens exert their opposing effects on prostate tumor growth through ERβ and KLF5, but through distinct mechanisms.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/ra22?etoc - Immunology
PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes - Suhasini Kulkarni, Cassian Sitaru, Zoltan Jakus, Karen E. Anderson, George Damoulakis, Keith Davidson, Misa Hirose, Jatinder Juss, David Oxley, Tamara A. M. Chessa, Faruk Ramadani, Herve Guillou, Anne Segonds-Pichon, Anja Fritsch, Gavin E. Jarvis, Klaus Okkenhaug, Ralf Ludwig, Detlef Zillikens, Attila Mocsai, Bart Vanhaesebroeck, Len R. Stephens, and Phillip T. Hawkins
- Sci. Signal. 4 (168), ra23. [DOI: 10.1126/scisignal.2001617]
The β isoform of phosphoinositide 3-kinase may be an effective therapeutic target in inflammatory diseases.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/ra23?etoc
Perspectives
- Cancer
Estrogen Receptor β: Switching to a New Partner and Escaping from Estrogen - Yuet-Kin Leung and Shuk-Mei Ho
- Sci. Signal. 4 (168), pe19. [DOI: 10.1126/scisignal.2001991]
ERβ promotes apoptosis in prostate cancer cells through an estrogen-independent mechanism.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/pe19?etoc
Editors' Choice
- Immunology
Mitochondrial Positioning in T Cells - John F. Foley
- Sci. Signal. 4 (168), ec99. [DOI: 10.1126/scisignal.4168ec99]
Recruitment of mitochondria by a fission factor to immune synapses in T cells modulates T cell receptor signal strength.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/ec99?etoc - Cell Migration
One Step at a Time - Nancy R. Gough
- Sci. Signal. 4 (168), ec100. [DOI: 10.1126/scisignal.4168ec100]
Cortical neurons rely on atypical Rho proteins Rnd2 and Rnd3 to inhibit RhoA in different compartments to allow proper migration during embryonic development.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/ec100?etoc - Immunology
Eosinophils and Metabolism - Kristen L. Mueller
- Sci. Signal. 4 (168), ec101. [DOI: 10.1126/scisignal.4168ec101]
Regulation of adipose tissue macrophages by eosinophils reveals an unexpected role for eosinophils in metabolic homeostasis.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/ec101?etoc - Cell Biology
Rac1 Regulates Both mTORC Complexes - Elizabeth M. Adler
- Sci. Signal. 4 (168), ec102. [DOI: 10.1126/scisignal.4168ec102]
Rac1 binds to mTOR, influencing the localization and activity of both mTORC1 and mTORC2.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/ec102?etoc - Plant Biology
Polarized by the Light - Wei Wong
- Sci. Signal. 4 (168), ec103. [DOI: 10.1126/scisignal.4168ec103]
Light-dependent phosphorylation of the auxin efflux carrier PIN3 determines its trafficking pattern in the hypocotyl endodermis.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/ec103?etoc - Regeneration
Recovering from Bladder Injury - Nancy R. Gough
- Sci. Signal. 4 (168), ec104. [DOI: 10.1126/scisignal.4168ec104]
Hedgehog signaling activates Wnt signaling to promote regeneration of the bladder urothelium after chemical injury or injury due to infection.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/ec104?etoc - Neuronal Polarization
Energy Requirements for Neuronal Polarization - Stella M. Hurtley
- Sci. Signal. 4 (168), ec105. [DOI: 10.1126/scisignal.4168ec105]
A bioenergy-sensing pathway determines axon initiation and growth in neurons.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/168/ec105?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to:
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- - - - - - - - Sponsored by Science Business Office - - - - - - - -
Watch Previously Recorded Webinars from AAAS/Science
View our collection of over 25 webinars on www.sciencemag.org/webinar
and learn how today's research is shaping tomorrow's discoveries.
Featuring presentations from world renowned experts on a broad range
of topics, including Noncoding RNAs, Apoptosis, qPCR, Next-Gen
Sequencing, and Stem Cell Research, the webinars are a tremendous
learning tool that include previously recorded question and answer
segments.
Watch Science Webinars today at www.sciencemag.org/webinar.
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