Science Podcast In this week's show: Targeted cancer therapy, progress with cancer genomes, mechanisms of metastasis, immunity's role in cancer, and more. Listen now.
Want to add other e-mail alerts? Change your preferences? Cancel alerts? Log in at http://www.sciencemag.org/cgi/etoc!
In this week's issue:
Editorial
The Challenge of Cancer
Bruce Alberts
http://www.sciencemag.org/cgi/content/summary/331/6024/1491
Research Summaries
This Week in Science
Editor summaries of this week's papers.
http://www.sciencemag.org/content/vol331/issue6024/twis.dtl
Editors' Choice
Highlights of the recent literature
http://www.sciencemag.org/content/vol331/issue6024/twil.dtl
News of the Week
This Week's Section
http://www.sciencemag.org/cgi/content/summary/331/6024/1499-a
Around the World
In science news around the world this week, U.K. scientists are welcoming proposed changes to libel law, an oil spill is threatening endangered penguins in Tristan da Cunha, European space scientists are scrambling to rethink—and redesign—massive potential missions that NASA won't be helping support as planned, a model farm devoted to raising insects as food is set to open at the National University of Laos, and seven Guatemalan plaintiffs have filed suit in response to unethical medical studies run by U.S.-funded scientists in Guatemala in the 1940s.
http://www.sciencemag.org/cgi/content/summary/331/6024/1499-b
Newsmakers
This week's Newsmakers are Evan O'Dorney, who won first place and $100,000 in the Intel Science Talent Search; three stem cell scientists whose work will share this year's Albany Medical Center Prize in Medicine and Biomedical Research and its accompanying $500,000; and seven medical researchers who have won Canada's Gairdner Foundation Awards, valued at CAD $100,000 each.
http://www.sciencemag.org/cgi/content/summary/331/6024/1500-a
Random Sample
Space scientists at the University of Leicester are working to protect the people of Britain from a terrifying scourge: counterfeit whisky. And this week's numbers quantify the cost to ferry U.S. astronauts to the International Space Station aboard Soyuz spacecraft, the percentage of MIT's science and engineering faculty who are women, and the number of homes that could run on an underwater turbine array just authorized by the Scottish government.
http://www.sciencemag.org/cgi/content/summary/331/6024/1500-b
Findings
http://www.sciencemag.org/content/vol331/issue6024/findings.dtl
News & Analysis
Nuclear Power's Global Fallout
Science has created a map that provides a snapshot of the number of nuclear reactors in operation and under construction worldwide, locations of power plants in relation to seismic hazard zones, and reactions to events in Japan in some countries.
http://www.sciencemag.org/cgi/content/summary/331/6024/1502
Radiation Risks Outlined by Bombs, Weapons Work, and Accidents
Risk calculations for radiation exposure are based heavily on a 63-year study of 94,000 people who survived the two atomic bombs dropped on Japan in August 1945. It is one of the largest, longest population studies ever done; for radiation safety, it is the gold standard.
http://www.sciencemag.org/cgi/content/summary/331/6024/1504
Candidate Radiation Drugs Inch Forward
Over the past 5 years, a few promising candidate drugs designed to ward off the effects of radiation exposure have begun to undergo animal, and even human, testing. Still, only a few companies and academic groups are addressing this unmet need.
http://www.sciencemag.org/cgi/content/summary/331/6024/1505
Current Designs Address Safety Problems in Fukushima Reactors
Nuclear reactor designers say that the reactors being built or planned today are quite different—and they say much safer—than those that are still smoldering in Japan.
http://www.sciencemag.org/cgi/content/summary/331/6024/1506
Fukushima Cleanup Will Be Drawn Out and Costly
The Fukushima cleanup operation is likely to resemble the protracted cleanup at the Three Mile Island Nuclear Generating Station in Pennsylvania, where one reactor experienced a partial meltdown in 1979.
http://www.sciencemag.org/cgi/content/summary/331/6024/1507
Japan's Research Facilities Down But Not Out
Japan's scientific community has been quietly taking stock of how extensively the magnitude-9 earthquake and subsequent tsunami on 11 March damaged facilities and experiments. The news is mixed.
http://www.sciencemag.org/cgi/content/summary/331/6024/1509
News Focus
Peak Oil Production May Already Be Here
Outside of OPEC's vast resources, oil production has leveled off, and it's looking like it may never rise again.
http://www.sciencemag.org/cgi/content/summary/331/6024/1510
Texas Site Confirms Pre-Clovis Settlement of the Americas
Very ancient stone tools help confirm what many have long suspected: Clovis hunters, with their distinctive spear points, were not the first to people the Americas.
http://www.sciencemag.org/cgi/content/summary/331/6024/1512
Going Viral: Exploring the Role Of Viruses in Our Bodies
'Virome' surveys reveal our vast number and variety of viruses.
http://www.sciencemag.org/cgi/content/summary/331/6024/1513
Letters
Dealing with Data: Fostering Fidelity
http://www.sciencemag.org/cgi/content/full/331/6024/1515-a
Dealing with Data: Preserve Old Collections
http://www.sciencemag.org/cgi/content/full/331/6024/1515-b
Dealing with Data: Upgrading Infrastructure
http://www.sciencemag.org/cgi/content/full/331/6024/1515-c
Dealing with Data: Training New Scientists
http://www.sciencemag.org/cgi/content/full/331/6024/1516-a
Advancing Translational Research
http://www.sciencemag.org/cgi/content/full/331/6024/1516-b
Corrections and Clarifications
http://www.sciencemag.org/cgi/content/full/331/6024/1517
Books et al.
A Better View of Eras of Life
Stuart West
Synthesizing theoretical and empirical perspectives, Bourke presents an expanded view of social evolution to explain the major transitions between successive levels in the biological hierarchy.
http://www.sciencemag.org/cgi/content/summary/331/6024/1519
A Ballet of Plant Movement
Sarah E. Wyatt
Writing for nonspecialists, Koller collects experimental findings (many from his own research) to discuss the mechanisms and adaptive value of plant movements.
http://www.sciencemag.org/cgi/content/summary/331/6024/1520-a
Books Received
A listing of books received at Science during the week ended 18 March 2011.
http://www.sciencemag.org/cgi/content/summary/331/6024/1520-b
Policy Forum
Marine Biodiversity and Gene Patents
S. Arnaud-Haond et al.
Ten countries account for 90% of patent claims associated with marine genes, including some from international waters.
http://www.sciencemag.org/cgi/content/summary/331/6024/1521
Perspectives
A New Focus on RNA in the Lens
Melinda K. Duncan
A protein forms granules with RNA to control gene expression and mammalian eye lens development.
http://www.sciencemag.org/cgi/content/summary/331/6024/1523
Antarctica's Deep Frozen "Lakes"
S. Tulaczyk and S. Hossainzadeh
Airborne radar surveys performed over East Antarctica reveal massive and widespread bodies of accreted basal ice.
http://www.sciencemag.org/cgi/content/summary/331/6024/1524
On Dental Occlusion and Saber Teeth
Jörg Fröbisch
An early mammal relative from Brazil offers insight into the early evolution of herbivory.
http://www.sciencemag.org/cgi/content/summary/331/6024/1525
Electronic Bonding Revealed by Electron Diffraction
Paul A. Midgley
A new electron diffraction method reveals a tetrahedral bond network in aluminum that can account for the directional nature of its mechanical properties.
http://www.sciencemag.org/cgi/content/summary/331/6024/1528
Selective Insulin Sensitizers
J. Y. Kim-Muller and D. Accili
Can the liver's insensitivity to insulin in diabetes be overcome with another hormone?
http://www.sciencemag.org/cgi/content/summary/331/6024/1529
An Earlier Acheulian Arrival in South Asia
Robin Dennell
Early stone tools found in India alter our view of how a key technology spread from Africa.
http://www.sciencemag.org/cgi/content/summary/331/6024/1532
A Helix for the Final Cut
C. Raiborg and H. Stenmark
The constriction of a protein helix and the action of a microtubule-severing enzyme trigger the final stage of separation during cell division.
http://www.sciencemag.org/cgi/content/summary/331/6024/1533
Research Articles
Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma
S. A. Lachke et al.
A Tudor domain protein mediates posttranscriptional control of gene expression and is required for eye-lens development.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1571
Reports
Baryons at the Edge of the X-ray–Brightest Galaxy Cluster
A. Simionescu et al.
The Suzaku satellite provides a census of the gas, metals, and dark matter out to the outskirts of the Perseus Cluster.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1576
From a Single-Band Metal to a High-Temperature Superconductor via Two Thermal Phase Transitions
R.-H. He et al.
Three techniques are used to probe the pseudogap state of cuprate high-temperature superconductors.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1579
The Bonding Electron Density in Aluminum
P. N. H. Nakashima et al.
A combination of microscopy and first-principle calculations is used to study the bonding charge density in aluminum.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1583
Revealing Extraordinary Intrinsic Tensile Plasticity in Gradient Nano-Grained Copper
T. H. Fang et al.
Nanometer-sized grain copper confined by a graded substrate leads to a material with both high strength and high ductility.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1587
Self-Recognition Among Different Polyprotic Macroions During Assembly Processes in Dilute Solution
T. Liu et al.
Differences in surface charge and water mobility allow slightly different inorganic macroions to self-assemble separately.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1590
Widespread Persistent Thickening of the East Antarctic Ice Sheet by Freezing from the Base
R. E. Bell et al.
A large fraction of the ice at Dome A, Antarctica, did not form by the usual process of snowfall compaction.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1592
Early Pleistocene Presence of Acheulian Hominins in South India
S. Pappu et al.
Dates from a site in southeast India imply an early migration of Homo through Eurasia about 1.1 to 1.5 million years ago.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1596
The Buttermilk Creek Complex and the Origins of Clovis at the Debra L. Friedkin Site, Texas
M. R. Waters et al.
A large artifact assemblage dating to 15,000 years ago lies beneath a Clovis assemblage in central Texas.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1599
Dental Occlusion in a 260-Million-Year-Old Therapsid with Saber Canines from the Permian of Brazil
J. C. Cisneros et al.
Tiarajudens extends the date of dental occlusion and suggests why the members of this Permian group were such diverse and successful herbivores.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1603
Social and Ecological Synergy: Local Rulemaking, Forest Livelihoods, and Biodiversity Conservation
L. Persha et al.
Participation in tropical forest governance by local people results in positive outcomes for conservation and subsistence.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1606
Impacts of Salmon on Riparian Plant Diversity
M. D. Hocking and J. D. Reynolds
A survey of Canadian forests reveals the effects of nutrient subsidies from salmon on plant community structure.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1609
CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
G. L. Beatty et al.
CD40 immunotherapy shows efficacy in treating pancreatic cancer in mice and humans by eliciting antitumor immunity.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1612
Cortical Constriction During Abscission Involves Helices of ESCRT-III–Dependent Filaments
J. Guizetti et al.
The process by which animal cells are physically separated after cell division is dissected in molecular detail.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1616
FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
S. Kir et al.
Fibroblast growth factor 19 regulates liver metabolism through a mechanism distinct from that of insulin.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1621
Clr4/Suv39 and RNA Quality Control Factors Cooperate to Trigger RNAi and Suppress Antisense RNA
K. Zhang et al.
A histone methyltransferase and an RNA export protein team up to clobber aberrant RNAs in fission yeast.
http://www.sciencemag.org/cgi/content/abstract/331/6024/1624
Departments
New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
http://www.sciencemag.org/cgi/content/summary/331/6024/1631-a
Science Podcast
http://www.sciencemag.org/cgi/content/summary/331/6024/1631-b
AAAS News and Notes
http://www.sciencemag.org/cgi/content/summary/331/6024/1537
From the AAAS Office of Publishing and Member Services
LIFE SCIENCE TECHNOLOGIES: Synthetic Genomics - Building a Better Bacterium
Jeffrey M. Perkel
http://www.sciencemag.org/cgi/content/summary/331/6024/1628
Unsubscribe or edit your subscriptions for this service at:
http://www.sciencemag.org/cgi/alerts/main
Written requests to unsubscribe may be sent to:
AAAS / Science, 1200 New York Avenue NW, Washington DC 20005, U.S.A.
Tidak ada komentar:
Posting Komentar