Science Signaling Table of Contents for 29 March 2011; Vol. 4, No. 166

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Watch Science Webinars today at www.sciencemag.org/webinar. >Science | >Science Signaling | >Science Translational Medicine | >Science Express | >Science Classic [About the cover] Science Signaling, Volume 4, Issue 166 dated 29 March 2011, is now available at: http://stke.sciencemag.org/content/vol4/issue166/?etoc  This week's issue of Science Signaling is part of the  online collection with Science, Science Careers, and  Science Translational Medicine related to cancer.  See more In this week's issue of Science Signaling: Editorial Guides Cancer Focus Issue: Rendering Resistance Futile Elizabeth M. Adler and Nancy R. Gough Sci. Signal. 4 (166), eg3. [DOI: 10.1126/scisignal.2002014] Understanding the pathways that mediate drug resistance is key to developing new cancer therapies. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/eg3?etoc Research Articles Cancer Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells Annette S. Little, Kathryn Balmanno, Matthew J. Sale, Scott Newman, Jonathan R. Dry, Mark Hampson, Paul A. W. Edwards, Paul D. Smith, and Simon J. Cook Sci. Signal. 4 (166), ra17. [DOI: 10.1126/scisignal.2001752] Resistance to cancer therapeutics targeting the second kinase in a three-kinase cascade involves amplification of the upstream kinase, not the inhibited kinase. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/ra17?etoc Cancer Global Phosphoproteomics Reveals Crosstalk Between Bcr-Abl and Negative Feedback Mechanisms Controlling Src Signaling Liudmilla Rubbi, Björn Titz, Lauren Brown, Erica Galvan, Evangelia Komisopoulou, Sharon S. Chen, Tracey Low, Martik Tahmasian, Brian Skaggs, Markus Müschen, Matteo Pellegrini, and Thomas G. Graeber Sci. Signal. 4 (166), ra18. [DOI: 10.1126/scisignal.2001314] Negative feedback fails to limit Src family kinase activity in the presence of Bcr-Abl, an oncoprotein that drives leukemia. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/ra18?etoc Cancer c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance Slovénie Pyndiah, Satoshi Tanida, Kazi M. Ahmed, Erica K. Cassimere, Chungyoul Choe, and Daitoku Sakamuro Sci. Signal. 4 (166), ra19. [DOI: 10.1126/scisignal.2001556] c-MYC promotes cisplatin resistance by enabling the increased activity of a DNA repair enzyme. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/ra19?etoc Perspectives Cancer MYC, PARP1, and Chemoresistance: BIN There, Done That? Shridar Ganesan Sci. Signal. 4 (166), pe15. [DOI: 10.1126/scisignal.2001946] Enhanced capacity for DNA repair may contribute to chemoresistance in cancers with dysregulated c-MYC. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/pe15?etoc Cancer Resistance to MEK Inhibitors: Should We Co-Target Upstream? Poulikos I. Poulikakos and David B. Solit Sci. Signal. 4 (166), pe16. [DOI: 10.1126/scisignal.2001948] Amplification of an upstream kinase in a three-kinase module confers resistance to cancer drugs that target a downstream kinase. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/pe16?etoc Editors' Choice Host-Pathogen Interactions Degraded for Shock Value Wei Wong Sci. Signal. 4 (166), ec89. [DOI: 10.1126/scisignal.4166ec89] A glycoprotein secreted by a parasitic nematode inhibits TLR4 signaling and could be used to treat sepsis. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/ec89?etoc Immunology Activated by Cleavage John F. Foley Sci. Signal. 4 (166), ec90. [DOI: 10.1126/scisignal.4166ec90] An avian Toll-like receptor is cleaved and activated by virulence-associated fungal and bacterial proteases. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/ec90?etoc Cancer Immunotherapy Pancreatic Cancer Immunotherapy Kristen L. Mueller Sci. Signal. 4 (166), ec91. [DOI: 10.1126/scisignal.4166ec91] CD40 immunotherapy shows efficacy in treating pancreatic cancer in mice and humans by eliciting antitumor immunity. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/ec91?etoc Development From Fat Body to Glia to Neuroblasts Elizabeth M. Adler Sci. Signal. 4 (166), ec92. [DOI: 10.1126/scisignal.4166ec92] A fat-body–derived signal to glia leads to their release of insulin-like peptides to stimulate neuroblast reactivation. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/ec92?etoc Metabolism FGF19 and Liver Metabolism L. Bryan Ray Sci. Signal. 4 (166), ec93. [DOI: 10.1126/scisignal.4166ec93] Fibroblast growth factor 19 regulates liver metabolism through a mechanism distinct from that of insulin. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/ec93?etoc Podcasts Cancer Science Signaling Podcast: 29 March 2011 Thomas G. Graeber and Annalisa M. VanHook Sci. Signal. 4 (166), pc6. [DOI: 10.1126/scisignal.2001941] Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/166/pc6?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to: AAAS / Science, 1200 New York Avenue NW, Washington DC 20005, U.S.A.     News | Journals | Careers | Blogs | Multimedia | Collections | Help | Site Map | RSS Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us © 2009 American Association for the Advancement of Science. All Rights Reserved. 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