Science Signaling Table of Contents for 22 March 2011; Vol. 4, No. 165

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Watch Science Webinars today at www.sciencemag.org/webinar. >Science | >Science Signaling | >Science Translational Medicine | >Science Express | >Science Classic [About the cover] Science Signaling, Volume 4, Issue 165 dated 22 March 2011, is now available at: http://stke.sciencemag.org/content/vol4/issue165/?etoc  Science Signaling: Print Edition  Weekly online and monthly in print  Learn more In this week's issue of Science Signaling: Funding Sources Check out the new opportunities for funding signaling research and training. Learn more Research Articles Systems Biology In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-α–Induced Apoptosis and Proliferation by MAPKs Ken S. Lau, Alwin M. Juchheim, Kimberly R. Cavaliere, Sarah R. Philips, Douglas A. Lauffenburger, and Kevin M. Haigis Sci. Signal. 4 (165), ra16. [DOI: 10.1126/scisignal.2001338] A systems-level analysis of signaling in the mouse intestine identifies critical mediators of inflammation and regionally specific responses. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/ra16?etoc Perspectives Immunology CD69: An Unexpected Regulator of TH17 Cell–Driven Inflammatory Responses Pilar Martín and Francisco Sánchez-Madrid Sci. Signal. 4 (165), pe14. [DOI: 10.1126/scisignal.2001825] CD69 deficiency promotes differentiation of inflammatory TH17 cells and exacerbates autoimmune diseases in mice. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/pe14?etoc Editors' Choice Cancer Getting Rid of Unwanted Neighbors Wei Wong Sci. Signal. 4 (165), ec82. [DOI: 10.1126/scisignal.4165ec82] JNK signaling promotes the elimination of neoplastic cells in Drosophila epithelia. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/ec82?etoc Vitamin A Signaling Retinol Gets In on the Act John F. Foley Sci. Signal. 4 (165), ec83. [DOI: 10.1126/scisignal.4165ec83] The binding of vitamin A to its uptake receptor activates JAK-STAT signaling and gene expression. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/ec83?etoc Reproduction Activating CatSper Elizabeth M. Adler Sci. Signal. 4 (165), ec84. [DOI: 10.1126/scisignal.4165ec84] Progesterone stimulates calcium influx in human sperm through the CatSper channel. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/ec84?etoc Transcription Chromatin-Associated PKC Nancy R. Gough Sci. Signal. 4 (165), ec85. [DOI: 10.1126/scisignal.4165ec85] Protein kinase C- acts directly at gene promoters to participate in inducible gene expression. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/ec85?etoc Innate Immunity Unexpected Inhibition Annalisa M. VanHook Sci. Signal. 4 (165), ec86. [DOI: 10.1126/scisignal.4165ec86] Ras-MAPK signaling modulates innate immunity in the fly. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/ec86?etoc Neuroscience The Brain’s Alarm Clock Pamela J. Hines Sci. Signal. 4 (165), ec87. [DOI: 10.1126/scisignal.4165ec87] Neurons in the brain that boost the morning response of the circadian rhythm are themselves directly responsive to light. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/ec87?etoc Cardiac Physiology Limiting Heart Hypertrophy Nancy R. Gough Sci. Signal. 4 (165), ec88. [DOI: 10.1126/scisignal.4165ec88] Reducing the abundance of follistatin-like 3, a secreted antagonist of members of the transforming growth factor–β family, reduces cardiac hypertrophy. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/ec88?etoc Meeting Reports IMMUNOLOGY The Yin and Yang of Signaling in Tregs and TH17 Cells Fan Pan, Huimin Fan, Ling Lu, Zhongmin Liu, and Shuiping Jiang Sci. Signal. 4 (165), mr4. [DOI: 10.1126/scisignal.2001709] This meeting in Shanghai focused on the relationship between regulatory and inflammatory T cells. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/165/mr4?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to: AAAS / Science, 1200 New York Avenue NW, Washington DC 20005, U.S.A.     News | Journals | Careers | Blogs | Multimedia | Collections | Help | Site Map | RSS Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us © 2009 American Association for the Advancement of Science. All Rights Reserved. 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