Science Signaling Table of Contents for 15 March 2011; Vol. 4, No. 164

- - - - - - - - - Sponsored by SwitchGear Genomics - - - - - - - - - See the Light. Make the Switch. Stop Cloning! The LightSwitch Luciferase Assay System provides everything you need for reporter assays: pre-cloned human promoters and 3'UTRs in luciferase reporter vectors and optimized luciferase reagents to measure promoter induction and miRNA target validation. Visit SwitchGear Genomics and explore our genome-wide collections and validated pathway sets. >Science | >Science Signaling | >Science Translational Medicine | >Science Express | >Science Classic [About the cover] Science Signaling, Volume 4, Issue 164 dated 15 March 2011, is now available at: http://stke.sciencemag.org/content/vol4/issue164/?etoc  Explore the personalization options available at Science Signaling.  Details In this week's issue of Science Signaling: Research Articles Cell Biology LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gαs Mei Wan, Jun Li, Katie Herbst, Jin Zhang, Bing Yu, Xiangwei Wu, Tao Qiu, Weiqi Lei, Charlotta Lindvall, Bart O. Williams, Hairong Ma, Fengjie Zhang, and Xu Cao Sci. Signal. 4 (164), ra15. [DOI: 10.1126/scisignal.2001464] The receptor LRP6 associates with Gαs to promote cAMP signaling by various GPCRs. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/ra15?etoc Research Resources Techniques Engineering the ABA Plant Stress Pathway for Regulation of Induced Proximity Fu-Sen Liang, Wen Qi Ho, and Gerald R. Crabtree Sci. Signal. 4 (164), rs2. [DOI: 10.1126/scisignal.2001449] An abscisic acid–induced proximity system can be used in combination with other such systems to simultaneously control multiple cellular processes. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/rs2?etoc Phosphoproteomics System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation Kristoffer T. G. Rigbolt, Tatyana A. Prokhorova, Vyacheslav Akimov, Jeanette Henningsen, Pia T. Johansen, Irina Kratchmarova, Moustapha Kassem, Matthias Mann, Jesper V. Olsen, and Blagoy Blagoev Sci. Signal. 4 (164), rs3. [DOI: 10.1126/scisignal.2001570] Dynamic phosphorylation during stem cell differentiation may control recruitment of DNA methyltransferases to silence genes that maintain pluripotency. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/rs3?etoc Perspectives Methods Inducible Gene Expression in Mammals: Plants Add to the Menu Sean R. Cutler Sci. Signal. 4 (164), pe13. [DOI: 10.1126/scisignal.2001875] The plant abscisic acid signaling components can be leveraged to inducibly control protein interactions in mammals. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/pe13?etoc Editors' Choice Cancer Healed into Cancer Nancy R. Gough Sci. Signal. 4 (164), ec74. [DOI: 10.1126/scisignal.4164ec74] Recruitment of hair stem cells with activating mutations in the Hedgehog pathway to sites of skin injury leads to tumor formation. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/ec74?etoc Immunology Inflamed About Retinoic Acid Elizabeth M. Adler Sci. Signal. 4 (164), ec75. [DOI: 10.1126/scisignal.4164ec75] In the presence of interleukin-15, retinoic acid appears to promote an intestinal inflammatory response. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/ec75?etoc Sensory Perception Feeling the Heat L. Bryan Ray Sci. Signal. 4 (164), ec76. [DOI: 10.1126/scisignal.4164ec76] The light sensor rhodopsin appears to function also in temperature sensation in the fruit fly. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/ec76?etoc Structural Biology Messing with the Brakes John F. Foley Sci. Signal. 4 (164), ec77. [DOI: 10.1126/scisignal.4164ec77] An additional point of contact with its regulatory subunit distinguishes p110β from other class IA PI3K isoforms. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/ec77?etoc Neuroscience Forcefully Translated Wei Wong Sci. Signal. 4 (164), ec78. [DOI: 10.1126/scisignal.4164ec78] Activation of integrins on oligodendrocytes promotes translation of the mRNA encoding a myelin sheath component. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/ec78?etoc Host-Pathogen Interactions Bacterial-Host Exploitation Stella M. Hurtley Sci. Signal. 4 (164), ec79. [DOI: 10.1126/scisignal.4164ec79] A virulence factor secreted by Listeria monocytogenes induces expression of interferon-stimulated genes. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/ec79?etoc Circadian Rhythms Metabolic Lags L. Bryan Ray Sci. Signal. 4 (164), ec80. [DOI: 10.1126/scisignal.4164ec80] Circadian control of liver metabolism is mediated by cycles of recruitment of the histone deacetylase HDAC3. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/ec80?etoc Evolution Tissues Simply Laura M. Zahn Sci. Signal. 4 (164), ec81. [DOI: 10.1126/scisignal.4164ec81] An epithelium in Dictyostelium discoideum suggests convergence between multicellular animals and slime molds. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/ec81?etoc Podcasts Thermosensation Science Signaling Podcast: 15 March 2011 Craig Montell and Annalisa M. VanHook Sci. Signal. 4 (164), pc5. [DOI: 10.1126/scisignal.2001923] A protein required for light sensation also plays a role in thermosensing in the fruit fly. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/164/pc5?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to: AAAS / Science, 1200 New York Avenue NW, Washington DC 20005, U.S.A.     News | Journals | Careers | Blogs | Multimedia | Collections | Help | Site Map | RSS Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us © 2009 American Association for the Advancement of Science. All Rights Reserved. AAAS is a partner of HINARI, AGORA, PatientInform, CrossRef, and COUNTER. - - - - - - - - - Sponsored by SwitchGear Genomics - - - - - - - - -   This e-mail was sent to bloggernyaagus.jawabansurat@blogger.com To get on and off our e-mail lists, please change your e-mail preferences here. 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