Science Signaling Table of Contents for 8 March 2011; Vol. 4, No. 163

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Watch Science Webinars today at www.sciencemag.org/webinar. >Science | >Science Signaling | >Science Translational Medicine | >Science Express | >Science Classic [About the cover] Science Signaling, Volume 4, Issue 163 dated 8 March 2011, is now available at: http://stke.sciencemag.org/content/vol4/issue163/?etoc  Science Signaling in F1000  Congratulations to Science Signaling authors of papers  featured in Faculty of 1000!  Details In this week's issue of Science Signaling: Events This list includes signaling-related meetings and conferences spanning methods to model organisms. Learn more Research Articles Cell Biology Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors Atsuo T. Sasaki, Arkaitz Carracedo, Jason W. Locasale, Dimitrios Anastasiou, Koh Takeuchi, Emily Rose Kahoud, Sasson Haviv, John M. Asara, Pier Paolo Pandolfi, and Lewis C. Cantley Sci. Signal. 4 (163), ra13. [DOI: 10.1126/scisignal.2001518] Cancers in which K-Ras activation drives tumor growth could be targeted by treatments blocking K-Ras ubiquitination. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ra13?etoc Immunology Vav1-Mediated Scaffolding Interactions Stabilize SLP-76 Microclusters and Contribute to Antigen-Dependent T Cell Responses Nicholas R. Sylvain, Ken Nguyen, and Stephen C. Bunnell Sci. Signal. 4 (163), ra14. [DOI: 10.1126/scisignal.2001178] Scaffolding functions of Vav1 contribute to SLP-76 clustering and signaling downstream of the T cell receptor. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ra14?etoc Perspectives Cell Biology Ubiquitin on Ras: Warden or Partner in Crime? Cathie M. Pfleger Sci. Signal. 4 (163), pe12. [DOI: 10.1126/scisignal.2001874] Ubiquitination of different Ras isoforms has distinct effects on abundance, activity, and access to effectors. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/pe12?etoc Editors' Choice Reproductive Biology Bones Promote Male Fertility L. Bryan Ray Sci. Signal. 4 (163), ec64. [DOI: 10.1126/scisignal.4163ec64] Osteocalcin, a peptide hormone produced in bone cells, controls production of the steroid hormone testosterone in the testes. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec64?etoc Cell Death Death by Lysosome Nancy R. Gough Sci. Signal. 4 (163), ec65. [DOI: 10.1126/scisignal.4163ec65] A Stat3-regulated pathway leads to lysosomal membrane permeabilization and reduced inhibition of cathepsin activity to promote mammary gland involution. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec65?etoc Cell Biology Eliminating Unnecessary Repair Machinery? Elizabeth M. Adler Sci. Signal. 4 (163), ec66. [DOI: 10.1126/scisignal.4163ec66] Acetylation coordinates the DNA double-strand break processing with autophagy. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec66?etoc Neuroscience FATtening Up Against Neurodegeneration Wei Wong Sci. Signal. 4 (163), ec67. [DOI: 10.1126/scisignal.4163ec67] A neurodegenerative disorder could be caused by decreased signaling through the Hippo pathway. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec67?etoc Cell Biology mTORC Acid Test Annalisa M. VanHook Sci. Signal. 4 (163), ec68. [DOI: 10.1126/scisignal.4163ec68] Amino acids induce signaling through mTORC2. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec68?etoc MAPK Signaling Dual Mode of Oncogenesis Nancy R. Gough Sci. Signal. 4 (163), ec69. [DOI: 10.1126/scisignal.4163ec69] Oncogenic Ras mutants stimulate the first kinase in the MAPK pathway (Raf) and prevent SUMOylation-mediated inhibition of the second kinase, MEK. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec69?etoc Development Sizing Signals Stella M. Hurtley Sci. Signal. 4 (163), ec70. [DOI: 10.1126/scisignal.4163ec70] Mitosis starts when morphogen signaling levels have increased by half since the beginning of the cell cycle. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec70?etoc Plant Biology Break It Down, Sweep It Out Pamela J. Hines Sci. Signal. 4 (163), ec71. [DOI: 10.1126/scisignal.4163ec71] Natural-product effectors of disease resistance in Arabidopsis reveal complementary disabling mechanisms in the pathogen. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec71?etoc Cancer Biology Netting Pancreatic Cancer Genes Paula A. Kiberstis Sci. Signal. 4 (163), ec72. [DOI: 10.1126/scisignal.4163ec72] A rare but deadly form of human pancreatic cancer harbors mutations in chromatin remodeling genes. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec72?etoc Neuroscience Improving Old Memories Peter R. Stern Sci. Signal. 4 (163), ec73. [DOI: 10.1126/scisignal.4163ec73] In rats, overexpression of a persistently active protein kinase C isoform enhances memories long after they have been formed. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/ec73?etoc Podcasts Development Science Signaling Podcast: 8 March 2011 Marcos González-Gaitán, Frank Jülicher, and Annalisa M. VanHook Sci. Signal. 4 (163), pc4. [DOI: 10.1126/scisignal.2001924] Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/163/pc4?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to: AAAS / Science, 1200 New York Avenue NW, Washington DC 20005, U.S.A.     News | Journals | Careers | Blogs | Multimedia | Collections | Help | Site Map | RSS Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us © 2009 American Association for the Advancement of Science. All Rights Reserved. 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