Science Signaling Table of Contents for 15 February 2011; Vol. 4, No. 160

- - - - - - - - - - - - Sponsored by ATCC - - - - - - - - - - - - >Science | >Science Signaling | >Science Translational Medicine | >Science Express | >Science Classic [About the cover] Science Signaling, Volume 4, Issue 160 dated 15 February 2011, is now available at: http://stke.sciencemag.org/content/vol4/issue160/?etoc    This week's issue complements the Science 11 February 2011 issue  "Dealing with Data" and all of the related content is free with  registration. Find out more about how to register. In this week's issue of Science Signaling: ST NetWatch Protein Databases Proteome Commons Description Technical Information Proteome Commons Tranche Repository Description Editorial Guides Scientific Communication Focus Issue: Conquering the Data Mountain Nancy R. Gough and Michael B. Yaffe Sci. Signal. 4 (160), eg2. [DOI: 10.1126/scisignal.2001871] Massive data sets create challenges for annotation, sharing, and presentation. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/eg2?etoc Research Articles Cancer MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop Rehan Ahmad, Hasan Rajabi, Michio Kosugi, Maya Datt Joshi, Maroof Alam, Baldev Vasir, Takeshi Kawano, Surender Kharbanda, and Donald Kufe Sci. Signal. 4 (160), ra9. [DOI: 10.1126/scisignal.2001426] An inflammatory response of epithelial cells may be co-opted to promote cancer cell survival. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/ra9?etoc Perspectives Biochemistry Effective Representation and Storage of Mass Spectrometry–Based Proteomic Data Sets for the Scientific Community Jesper V. Olsen and Matthias Mann Sci. Signal. 4 (160), pe7. [DOI: 10.1126/scisignal.2001839] Proteomics data need a reliability tag to allow scientists to discriminate among data sets in public repositories. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/pe7?etoc Biochemistry The Potential Cost of High-Throughput Proteomics Forest M. White Sci. Signal. 4 (160), pe8. [DOI: 10.1126/scisignal.2001813] The production of false leads by automated curation of high-throughput proteomic data sets exerts a toll on biological research and advancement. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/pe8?etoc Computational Biology Integrating Multiple Types of Data for Signaling Research: Challenges and Opportunities H. Steven Wiley Sci. Signal. 4 (160), pe9. [DOI: 10.1126/scisignal.2001826] Easy integration of biological data has enormous potential to drive advances in biology and medicine. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/pe9?etoc Computational Biology Setting the Standards for Signal Transduction Research Julio Saez-Rodriguez, Leonidas G. Alexopoulos, and Gustavo Stolovitzky Sci. Signal. 4 (160), pe10. [DOI: 10.1126/scisignal.2001844] Standardized methods to link large, complex data sets to models are needed. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/pe10?etoc Editors' Choice Neuroscience Notch for Neuronal Activity Wei Wong Sci. Signal. 4 (160), ec45. [DOI: 10.1126/scisignal.4160ec45] Notch signaling occurs in Drosophila olfactory receptor neurons and promotes synaptic plasticity in mouse hippocampal neurons. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/ec45?etoc Bone Stress Builds Bone Nancy R. Gough Sci. Signal. 4 (160), ec46. [DOI: 10.1126/scisignal.4160ec46] Without an intact ER stress pathway, osteoblasts fail to properly differentiate, resulting in skeletal dysplasia. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/ec46?etoc Channels Double-Trouble Mutation Paula A. Kiberstis Sci. Signal. 4 (160), ec47. [DOI: 10.1126/scisignal.4160ec47] Potassium channel mutations drive both cell growth and hormone production in an adrenal tumor that causes severe hypertension. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/ec47?etoc Cell Biology More or Less Durable Stella M. Hurtley Sci. Signal. 4 (160), ec48. [DOI: 10.1126/scisignal.4160ec48] In times of stress, long-lived proteins increase their durability. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/ec48?etoc Cell Biology Providing a Membrane Reservoir Elizabeth M. Adler Sci. Signal. 4 (160), ec49. [DOI: 10.1126/scisignal.4160ec49] Caveolae buffer variations in membrane tension during the response to acute mechanical stress. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/ec49?etoc Calcium Signaling Coupled by Caveolin Nancy R. Gough Sci. Signal. 4 (160), ec50. [DOI: 10.1126/scisignal.4160ec50] Interactions at the cell surface between the endoplasmic or sarcoplasmic reticulum localized inositol trisphosphate receptor and the plasma membrane localized transient receptor potential 3 are mediated by caveolin-1. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/ec50?etoc Host-Pathogen Interactions Parasites Ad Infinitum Caroline Ash Sci. Signal. 4 (160), ec51. [DOI: 10.1126/scisignal.4160ec51] An RNA virus of a parasite binds to human Toll-like receptor 3 and modulates host immune responses to the parasite. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/ec51?etoc Microbiology Deadly Switch Stella M. Hurtley Sci. Signal. 4 (160), ec52. [DOI: 10.1126/scisignal.4160ec52] Regulated deaggregation allows meningitis-causing bacteria to propagate to new host cells and migrate across epithelia. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/ec52?etoc Presentations Scientific Communication Visual Representation of Scientific Information Bang Wong Sci. Signal. 4 (160), pt1. [DOI: 10.1126/scisignal.2001842] Judicious choice of graphical representations can improve visual communication. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/160/pt1?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to: AAAS / Science, 1200 New York Avenue NW, Washington DC 20005, U.S.A.     News | Journals | Careers | Blogs | Multimedia | Collections | Help | Site Map | RSS Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us © 2009 American Association for the Advancement of Science. All Rights Reserved. AAAS is a partner of HINARI, AGORA, PatientInform, CrossRef, and COUNTER.   This e-mail was sent to bloggernyaagus.jawabansurat@blogger.com To get on and off our e-mail lists, please change your e-mail preferences here. If you need additional help, please write to memuser@aaas.org . 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