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In this week's issue of Science Signaling:
Glossary
- Find out what Max, FRK, and TIMP mean in the world of cell signaling.
- New Terms | Search and Browse the Glossary
Research Articles
- G Proteins
The Crystal Structure of a Self-Activating G Protein  Subunit Reveals Its Distinct Mechanism of Signal Initiation - Janice C. Jones, Jeffrey W. Duffy, Mischa Machius, Brenda R. S. Temple, Henrik G. Dohlman, and Alan M. Jones
- Sci. Signal. 4 (159), ra8. [DOI: 10.1126/scisignal.2001446]
The Arabidopsis G protein subunit exhibits properties necessary and sufficient for receptor-independent activation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ra8?etoc
Perspectives
- Structural Biology
Gq and Phospholipase C-β: Turn On, Turn Off, and Do It Fast - Elliott M. Ross
- Sci. Signal. 4 (159), pe5. [DOI: 10.1126/scisignal.2001798]
A crystal structure illuminates reciprocal regulation between a G protein and its effector.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/pe5?etoc - Cell Migration
How Cells Use Pseudopods for Persistent Movement and Navigation - Peter J. M. Van Haastert
- Sci. Signal. 4 (159), pe6. [DOI: 10.1126/scisignal.2001708]
A model of pseudopod formation, splitting, and persistence describes how cells migrate.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/pe6?etoc
Editors' Choice
- DNA Damage Response
Repair and Protect - Nancy R. Gough
- Sci. Signal. 4 (159), ec35. [DOI: 10.1126/scisignal.4159ec35]
By stimulating metabolic flux through the pentose phosphate pathway, ATM promotes the production of nucleotides for DNA repair and limits production of reactive oxygen species.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec35?etoc - Glycosylation
Making It Short and Sweet - Elizabeth M. Adler
- Sci. Signal. 4 (159), ec36. [DOI: 10.1126/scisignal.4159ec36]
O-linked β-N-acetylglucosamine transferase cleaves HCF-1, as well as glycosylating it, in a process necessary for its functional activation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec36?etoc - Lymphoma
Oncogenic MyD88 - John F. Foley
- Sci. Signal. 4 (159), ec37. [DOI: 10.1126/scisignal.4159ec37]
A gain-of-function mutation in MyD88 promotes survival of a B cell lymphoma through activation of NF- B and JAK-STAT signaling pathways.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec37?etoc - Immunology
Limiting Inflammatory Signaling with EPO - Nancy R. Gough
- Sci. Signal. 4 (159), ec38. [DOI: 10.1126/scisignal.4159ec38]
Erythropoietin inhibits NF-B activation in macrophages and thus limits proinflammatory signaling.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec38?etoc - RNA Processing
USE During Stress - Wei Wong
- Sci. Signal. 4 (159), ec39. [DOI: 10.1126/scisignal.4159ec39]
Stress-induced activation of p38 promotes more efficient processing of USE-containing mRNAs, including that encoding thrombin.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec39?etoc - Immunology
Wearing the Same Cap - Nancy R. Gough
- Sci. Signal. 4 (159), ec40. [DOI: 10.1126/scisignal.4159ec40]
Some viruses evade detection by encoding enzymes that modify the structures of their coding RNAs to match those of their hosts.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec40?etoc - Translation
Time for a Pause - Stella M. Hurtley
- Sci. Signal. 4 (159), ec41. [DOI: 10.1126/scisignal.4159ec41]
A peptide-mediated translational pause facilitates the unconventional splicing of a messenger RNA on the endoplasmic reticulum.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec41?etoc - Plant Biology
Not So Different After All - Annalisa M. VanHook
- Sci. Signal. 4 (159), ec42. [DOI: 10.1126/scisignal.4159ec42]
Dissociation of a plant receptor kinase inhibitor from its substrate is mediated by tyrosine phosphorylation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec42?etoc - Neuroscience
Variation in Transit - Peter R. Stern
- Sci. Signal. 4 (159), ec43. [DOI: 10.1126/scisignal.4159ec43]
The waveform of an action potential can be physiologically modified while it travels along the axon.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec43?etoc - Plant Biology
A Tale of Two Stomata - Pamela J. Hines
- Sci. Signal. 4 (159), ec44. [DOI: 10.1126/scisignal.4159ec44]
The transition from passive to active metabolic control of stomata and plant water balance occurred about 360 million years ago.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec44?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to:
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