Science Signaling Table of Contents for 25 January 2011; Vol. 4, No. 157

- - - - - - - - Sponsored by Science Business Office - - - - - - - - Watch Previously Recorded Webinars from AAAS/Science View our collection of over 25 webinars on www.sciencemag.org/webinar and learn how today's research is shaping tomorrow's discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at www.sciencemag.org/webinar. >Science | >Science Signaling | >Science Translational Medicine | >Science Express | >Science Classic [About the cover] Science Signaling, Volume 4, Issue 157 dated 25 January 2011, is now available at: http://stke.sciencemag.org/content/vol4/issue157/?etoc Check out the personalization features in Science Signaling. In this week's issue of Science Signaling: Research Articles Metabolism Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch Yoshikazu Hara, Shu Wakino, Yoshiyuki Tanabe, Maki Saito, Hirobumi Tokuyama, Naoki Washida, Satoru Tatematsu, Kyoko Yoshioka, Koichiro Homma, Kazuhiro Hasegawa, Hitoshi Minakuchi, Keiko Fujimura, Koji Hosoya, Koichi Hayashi, Koichi Nakayama, and Hiroshi Itoh Sci. Signal. 4 (157), ra3. [DOI: 10.1126/scisignal.2001227] Mechanical stretch activates Rho-kinase in adipocytes, promoting obesity and obesity-related complications. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/ra3?etoc Cell Biology Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling Leni S. Jacob, Xiaofeng Wu, Michael E. Dodge, Chih-Wei Fan, Ozlem Kulak, Baozhi Chen, Wei Tang, Baolin Wang, James F. Amatruda, and Lawrence Lum Sci. Signal. 4 (157), ra4. [DOI: 10.1126/scisignal.2001225] Loss of the kinase and tumor suppressor Stk11 (Lkb1) has opposite effects on Hh and Wnt signaling. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/ra4?etoc Neuroscience V2 Receptor–Mediated Autocrine Role of Somatodendritic Release of AVP in Rat Vasopressin Neurons Under Hypo-Osmotic Conditions Kaori Sato, Tomohiro Numata, Takeshi Saito, Yoichi Ueta, and Yasunobu Okada Sci. Signal. 4 (157), ra5. [DOI: 10.1126/scisignal.2001279] The antidiuretic hormone arginine vasopressin (AVP) is also an autocrine signal, allowing the hypothalamic neurons that produce it to maintain their volume during hypotonic stress. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/ra5?etoc Perspectives Cell Biology Control of DNMT1 Abundance in Epigenetic Inheritance by Acetylation, Ubiquitylation, and the Histone Code Christian Bronner Sci. Signal. 4 (157), pe3. [DOI: 10.1126/scisignal.2001764] The protein stability of a DNA methyltransferase is determined by acetylation and ubiquitylation. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/pe3?etoc Journal Club Immunology The Role of L(u)ck in T Cell Triggering Richard Berry Sci. Signal. 4 (157), jc2. [DOI: 10.1126/scisignal.2001657] The Src family kinase Lck is activated prior to T cell receptor engagement and poised for action upon antigen binding. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/jc2?etoc Editors' Choice Biochemistry Regulating Ras Trafficking with FKPB12 Nancy R. Gough Sci. Signal. 4 (157), ec23. [DOI: 10.1126/scisignal.4157ec23] By promoting Ras depalmitoylation, the prolyl isomerase FKBP12 regulates Ras trafficking and activity. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/ec23?etoc Lipid Rafts Lost Without a Raft Elizabeth M. Adler Sci. Signal. 4 (157), ec24. [DOI: 10.1126/scisignal.4157ec24] Cholesterol depletion enhances the proteolytic cleavage and release of the adhesion molecule CD44 and can inhibit glioma cell migration. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/ec24?etoc Angiogenesis A Roundabout Way to Vascularization Wei Wong Sci. Signal. 4 (157), ec25. [DOI: 10.1126/scisignal.4157ec25] Robo4 acts as an in trans ligand for UNC5B in vascular endothelium to restrict angiogenesis. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/ec25?etoc Autophagy Rallying the Troops John F. Foley Sci. Signal. 4 (157), ec26. [DOI: 10.1126/scisignal.4157ec26] A protein complex involved in the targeting of vesicles to the plasma membrane also acts as a platform for components of the autophagy machinery. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/ec26?etoc Virology Immune Evasion Tactic Kristen L. Mueller Sci. Signal. 4 (157), ec27. [DOI: 10.1126/scisignal.4157ec27] A viral homolog of a host microbial sensor inhibits viral detection by the host and subsequent antiviral immunity. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/ec27?etoc Immunology Clostridium to the Rescue Kristen L. Mueller Sci. Signal. 4 (157), ec28. [DOI: 10.1126/scisignal.4157ec28] Bacteria of the genus Clostridium promote the induction of suppressor T cells in the colons of mice. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/ec28?etoc Podcasts Mechanotransduction Science Signaling Podcast: 25 January 2011 Shu Wakino, Yasunobu Okada, and Annalisa M. VanHook Sci. Signal. 4 (157), pc2. [DOI: 10.1126/scisignal.2001824] Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/pc2?etoc Meeting Reports Cell Biology Dependence Receptors: From Basic Research to Drug Development Patrick Mehlen and Dale E. Bredesen Sci. Signal. 4 (157), mr2. [DOI: 10.1126/scisignal.2001521] Discussion at a meeting in France focused on new insights into the biology of dependence receptors. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/157/mr2?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to: AAAS / Science, 1200 New York Avenue NW, Washington DC 20005, U.S.A.     News | Journals | Careers | Blogs | Multimedia | Collections | Help | Site Map | RSS Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us © 2009 American Association for the Advancement of Science. All Rights Reserved. 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