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In this week's issue of Science Signaling:
Funding Sources
- Check out the 13 new opportunities for funding signaling research and training.
- Learn more
Glossary
- Find out what c-IAP1, MCC, and LKB1 mean in the world of cell signaling.
- New Terms | Search and Browse the Glossary
Research Articles
- Developmental Biology
The Kinase SGK1 in the Endoderm and Mesoderm Promotes Ectodermal Survival by Down-Regulating Components of the Death-Inducing Signaling Complex - Tatsuya Endo, Morioh Kusakabe, Kazunori Sunadome, Takuya Yamamoto, and Eisuke Nishida
- Sci. Signal. 4 (156), ra2. [DOI: 10.1126/scisignal.2001211]
The kinase SGK1 participates in an intertissue survival pathway during the early stages of development.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/ra2?etoc
Perspectives
- Genotoxic Stress
Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response - Kamyar Hadian and Daniel Krappmann
- Sci. Signal. 4 (156), pe2. [DOI: 10.1126/scisignal.2001712]
The kinase ATM has a cytosolic scaffolding function in the activation of NF-B in response to DNA damage.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/pe2?etoc
Editors' Choice
- Cell Biology
Inflammatory Mitochondria - Wei Wong
- Sci. Signal. 4 (156), ec15. [DOI: 10.1126/scisignal.4156ec15]
Reactive oxygen species generated by mitochondria can activate the NLRP3 inflammasome.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/ec15?etoc - Metabolism
Down with Ceramide - Nancy R. Gough
- Sci. Signal. 4 (156), ec16. [DOI: 10.1126/scisignal.4156ec16]
The adipocyte hormone adiponectin stimulates ceramidase activity of its receptors to promote its beneficial effects on cell survival and metabolism.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/ec16?etoc - Optogenetics
Using Light to Increase cAMP - Elizabeth M. Adler
- Sci. Signal. 4 (156), ec17. [DOI: 10.1126/scisignal.4156ec17]
A photoactivated adenylyl cyclase from the bacterium Beggiatoa represents a promising tool for optogenetic manipulation of cAMP.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/ec17?etoc - Circadian Clocks
Synchronize Your Watches - L. Bryan Ray
- Sci. Signal. 4 (156), ec18. [DOI: 10.1126/scisignal.4156ec18]
Cyanobacteral circadian clock components are directly coupled to the metabolic status of the cell through interactions with adenine nucleotides.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/ec18?etoc - Neuroscience
The Power of Women’s Tears - Peter R. Stern
- Sci. Signal. 4 (156), ec19. [DOI: 10.1126/scisignal.4156ec19]
Merely sniffing women's negative emotional tears reduces sexual arousal in men.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/ec19?etoc - Biophysics
Currents for GPCRs - Nancy R. Gough
- Sci. Signal. 4 (156), ec20. [DOI: 10.1126/scisignal.4156ec20]
The muscarinic acetylcholine receptor exhibits voltage-dependent gating currents that may enhance neurotransmitter release at cholinergic synapses.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/ec20?etoc - Computational Biology
Computer Scientists Learn from Flies - L. Bryan Ray
- Sci. Signal. 4 (156), ec21. [DOI: 10.1126/scisignal.4156ec21]
Modeling of development in the fruit fly yields an algorithm useful in designing wireless communication networks.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/ec21?etoc - Biochemistry
Controlling Inflammation - Valda Vinson
- Sci. Signal. 4 (156), ec22. [DOI: 10.1126/scisignal.4156ec22]
Substitution of a destabilizing sequence has allowed crystallization of a key enzyme of the inflammatory response.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/156/ec22?etoc
Errata
- A Correction to the Editors' Choice Summary Titled ''IP7 Akts as an Inhibitor'' by John F. Foley
- Sci. Signal. 4 (156), er1. [DOI: 10.1126/scisignal.4156er1]
The phenotypes of the wild-type and knockout mice were mistakenly transposed.
http://stke.sciencemag.org/cgi/content/full/sigtrans;4/156/er1?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to:
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Watch Previously Recorded Webinars from AAAS/Science
View our collection of over 25 webinars on www.sciencemag.org/webinar
and learn how today's research is shaping tomorrow's discoveries.
Featuring presentations from world renowned experts on a broad range
of topics, including Noncoding RNAs, Apoptosis, qPCR, Next-Gen
Sequencing, and Stem Cell Research, the webinars are a tremendous
learning tool that include previously recorded question and answer
segments.
Watch Science Webinars today at www.sciencemag.org/webinar.
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