Science Signaling Table of Contents for 4 January 2011; Vol. 4, No. 154

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Watch Science Webinars today at www.sciencemag.org/webinar. >Science | >Science Signaling | >Science Translational Medicine | >Science Express | >Science Classic [About the cover] Science Signaling, Volume 4, Issue 154 dated 4 January 2011, is now available at: http://stke.sciencemag.org/content/vol4/issue154/?etoc  Science Signaling: Print Edition  Weekly online and monthly in print  Learn more In this week's issue of Science Signaling: Editorial Guides Cell Biology 2010: Signaling Breakthroughs of the Year Elizabeth M. Adler Sci. Signal. 4 (154), eg1. [DOI: 10.1126/scisignal.2001770] The editors highlight the year's cell signaling breakthroughs. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/eg1?etoc Research Resources Cell Cycle A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint Shu Kondo and Norbert Perrimon Sci. Signal. 4 (154), rs1. [DOI: 10.1126/scisignal.2001350] The DNA damage response in Drosophila requires the replication preinitiation complex and the MUS312 nuclease complex. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/rs1?etoc Journal Club Plant Biology Protein S-Nitrosylation in Plants: Photorespiratory Metabolism and NO Signaling Kapuganti J. Gupta Sci. Signal. 4 (154), jc1. [DOI: 10.1126/scisignal.2001404] S-nitrosylation of mitochondrial proteins induces cell death in the plant pathogen defense response. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/jc1?etoc Editors' Choice Wnt Signaling Confined to Quarters? Elizabeth M. Adler Sci. Signal. 4 (154), ec1. [DOI: 10.1126/scisignal.4154ec1] Canonical Wnt signaling involves sequestration of glycogen synthase kinase 3. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/ec1?etoc Neuroscience Memory-Stealing Caspase Wei Wong Sci. Signal. 4 (154), ec2. [DOI: 10.1126/scisignal.4154ec2] Caspase-3 plays an apoptosis-independent role in the early pathogenesis of Alzheimer’s disease. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/ec2?etoc Physiology Understanding Atrophy Nancy R. Gough Sci. Signal. 4 (154), ec3. [DOI: 10.1126/scisignal.4154ec3] The scaffold and ubiquitin ligase TRAF6 plays a key role in muscle wasting. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/ec3?etoc Development Beyond Cell Cycle Control Annalisa M. VanHook Sci. Signal. 4 (154), ec4. [DOI: 10.1126/scisignal.4154ec4] A phosphatase normally associated with cell cycle control is required for ciliogenesis in zebrafish. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/ec4?etoc Neuroscience Exiting the Birthplace Pamela J. Hines Sci. Signal. 4 (154), ec5. [DOI: 10.1126/scisignal.4154ec5] A ubiquitination cascade regulates formation of cell adhesions that immature neurons require in the developing mouse brain. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/ec5?etoc Dependence Receptors PP2A, the Key to Life and Death Nancy R. Gough Sci. Signal. 4 (154), ec6. [DOI: 10.1126/scisignal.4154ec6] By recruiting active protein phosphatase 2A (PP2A) complexes or a PP2A inhibitor, the UNC5H2 dependence receptor triggers death or survival, respectively. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/ec6?etoc Structural Biology A Safety Catch on Immune Response Valda Vinson Sci. Signal. 4 (154), ec7. [DOI: 10.1126/scisignal.4154ec7] A double safety-catch mechanism controls amplification of the complement cascade during immune responses. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/ec7?etoc Metabolism Immune Protection from Metabolic Syndrome? Nancy R. Gough Sci. Signal. 4 (154), ec8. [DOI: 10.1126/scisignal.4154ec8] An immune profile that is biased toward the TH2 anti-inflammatory side regulates hepatic metabolism and limits adipose inflammation. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/ec8?etoc Evolution Exploiting Variation Guy Riddihough Sci. Signal. 4 (154), ec9. [DOI: 10.1126/scisignal.4154ec9] A molecular chaperone both buffers and potentiates the adaptive nature of genetic variation in yeast. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/ec9?etoc Podcasts Cell Biology Science Signaling Podcast: 4 January 2011 Michael B. Yaffe and Annalisa M. VanHook Sci. Signal. 4 (154), pc1. [DOI: 10.1126/scisignal.2001786] Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/154/pc1?etoc Unsubscribe or edit your subscriptions for this service at: http://www.sciencemag.org/cgi/alerts/main Written requests to unsubscribe may be sent to: AAAS / Science, 1200 New York Avenue NW, Washington DC 20005, U.S.A.     News | Journals | Careers | Blogs | Multimedia | Collections | Help | Site Map | RSS Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us © 2009 American Association for the Advancement of Science. All Rights Reserved. AAAS is a partner of HINARI, AGORA, PatientInform, CrossRef, and COUNTER. - - - - - - - - Sponsored by Science Business Office - - - - - - - - Watch Previously Recorded Webinars from AAAS/Science View our collection of over 25 webinars on www.sciencemag.org/webinar and learn how today's research is shaping tomorrow's discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at www.sciencemag.org/webinar.   This e-mail was sent to bloggernyaagus.jawabansurat@blogger.com To get on and off our e-mail lists, please change your e-mail preferences here. If you need additional help, please write to memuser@aaas.org . AAAS / Science 1200 New York Avenue NW Washington, DC 20005 U.S.A. Telephone: +1 202-326-6417 Toll Free in the U.S.: 866-434-(AAAS) 2227     E-mail:  membership@aaas.org Privacy Policy: http://www.sciencemag.org/help/readers/privacy.dtl   [ AAAS / Science does not endorse any 3rd party products or services advertised here. ]      © 2010 American Association for the Advancement of Science. All Rights Reserved. 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